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. 2014 Aug 8;15(3):156-60.
doi: 10.5152/jtgga.2014.13068. eCollection 2014.

Reproducibility of a time-lapse embryo selection model based on morphokinetic data in a sequential culture media setting

Ender Yalçınkaya  1 , Elif G Ergin  1 , Eray Calışkan  1 , Zeynep Oztel  1 , Alev Ozay  1 , Hakan Ozörnek  1
Affiliations

Reproducibility of a time-lapse embryo selection model based on morphokinetic data in a sequential culture media setting

Ender Yalçınkaya et al. J Turk Ger Gynecol Assoc. .

Abstract

Objective: To compare the outcomes of embryos that were given a dynamic score based on a preconstructed embryo scoring model and to analyze whether this model complies with our data.

Material and methods: A total of 910 transferred embryos with known implantation data were retrospectively analyzed in this study. All of the embryos were given a dynamic score based on the preconstructed hierarchical embryo scoring model.

Results: The highest pregnancy rate was seen in groups C+ and A- (48.2% for each), and the lowest was observed in Group E (19.7%). When implantation and clinical pregnancy rates were compared between groups, it was found that the highest and statistically significant implantation and clinical pregnancy rates were seen in group C+ (32.7% for each, p=0.000). They were dropped down to 29.4% in Group A-.

Conclusion: The outcomes of the embryos based on the dynamic score do not comply with the results of the preconstructed model. Each IVF laboratory is unique based on its practice. Therefore, we suggest that each IVF laboratory should determine its own embryo selection criteria based on its own data instead of using a preconstructed model.

Keywords: Preconstructed model; dynamic score; pregnancy rate.

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Figures

Figure 1
Figure 1
a, b. Figures above are two examples of transfer embryos at day 3. The photographs were captured by the camera system in time-lapse system. Embryo morphology looks similar; but dynamic scores based on embryo morphokinetics are different. Embryo with a dynamic score of A+ (a), Embryo with a dynamic score of C+ based on Meseguer’s scoring model (b)
Figure 2
Figure 2
Comparison of the clinical outcomes of the embryos with different dynamic scores (p<0.05)
See this image and copyright information in PMC

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