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Review
. 2014 Aug 1;9(15):1418-21.
doi: 10.4103/1673-5374.139454.

Molecular mechanisms of the suppression of axon regeneration by KLF transcription factors

Akintomide Apara  1 , Jeffrey L Goldberg  2
Affiliations
Review

Molecular mechanisms of the suppression of axon regeneration by KLF transcription factors

Akintomide Apara et al. Neural Regen Res. .

Abstract

Molecular mechanisms of the Krüppel-like family of transcription factors (KLFs) have been studied more in proliferating cells than in post-mitotic cells such as neurons. We recently found that KLFs regulate intrinsic axon growth ability in central nervous system (CNS) neurons including retinal ganglion cells, and hippocampal and cortical neurons. With at least 15 of 17 KLF family members expressed in neurons and at least 5 structurally unique subfamilies, it is important to determine how this complex family functions in neurons to regulate the intricate genetic programs of axon growth and regeneration. By characterizing the molecular mechanisms of the KLF family in the nervous system, including binding partners and gene targets, and comparing them to defined mechanisms defined outside the nervous system, we may better understand how KLFs regulate neurite growth and axon regeneration.

Keywords: axon growth; optic nerve; regeneration; retina; retinal ganglion cells; spinal cord; transcription factors.

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Conflict of interest statement

Conflicts of interest: The authors declare no conflicts of interest.

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