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. 2014 Oct 15;190(8):958-61.
doi: 10.1164/rccm.201406-1149LE.

Early intermittent hypoxia induces proatherogenic changes in aortic wall macrophages in a murine model of obstructive sleep apnea

Alex Gileles-Hillel  1 , Isaac Almendros, Abdelnaby Khalyfa, Shelley X Zhang, Yang Wang, David Gozal
Affiliations

Early intermittent hypoxia induces proatherogenic changes in aortic wall macrophages in a murine model of obstructive sleep apnea

Alex Gileles-Hillel et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Changes in macrophage populations in the aortic wall of mice exposed to intermittent hypoxia (IH) or room air (RA) during sleep for 6 weeks. (A) Representative example of fluorescence-activated cell sorter analysis of macrophages (CD11b and F4/80 positively labeled cells) and the increase in such population with IH. (B) Representative example of fluorescence-activated cell sorter analysis for CD64+ cells (resident macrophages) illustrating the reduction in resident macrophages after IH exposures. (C) IH is associated with significantly increased expression of CD36 in CD11b and F4/80 positively labeled cells indicating metabolic activation. (D) IH induced significant increases in Ly6C(hi) cell expression, indicating shifts toward proinflammatory macrophages recruited from the bone marrow. MFI = mean fluorescence intensity.
See this image and copyright information in PMC

References

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