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. 1989 Oct;26(1):125-31.
doi: 10.1016/0166-0934(89)90081-5.

Photodynamic inactivation of simian immunodeficiency virus

T C Chanh  1 , J S Allan, J L Matthews, F Sogandares-Bernal, M M Judy, H Skiles, J Leveson, A Marengo-Rowe, J T Newman
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Photodynamic inactivation of simian immunodeficiency virus

T C Chanh et al. J Virol Methods. 1989 Oct.

Abstract

A photodynamic flow system employing a dihematoporphyrin ether (DHE) was tested for its ability to inactivate the in vitro infectivity of simian immunodeficiency virus (SICMac) at 630 +/- 5 nm with a light fluence of 5 J/cm2. Cell-free SIVMac was inactivated by photoactivated hematoporphyrin derivative in a dose-dependent fashion. Since SIVMac is closely related to human immunodeficiency virus type 2 (HIV-2) and we have previously reported the successful photodynamic inactivation of HIV-1 in cell-free medium as well as in whole human blood, this technology has the potential for the eradication of transfusion-associated acquired immunodeficiency diseases caused by the above-mentioned retroviruses.

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