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. 2014 Nov 24;15(17):2489-93.
doi: 10.1002/cbic.201402432. Epub 2014 Oct 16.

Modular polyketide synthases (PKSs): a new model fits all?

Alexander Rittner  1 , Martin Grininger
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Modular polyketide synthases (PKSs): a new model fits all?

Alexander Rittner et al. Chembiochem. .

Abstract

Step-by-step to great diversity: With the potential to synthesize multi-millions of bioactive compounds, modular polyketide synthases (PKSs) are of great importance. In this Highlight, new developments in the understanding of the structure and function of these proteins are reviewed.

Keywords: cryo-EM; fatty acids; multienzymes; natural products; polyketides.

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