Bridging lipid metabolism and innate host defense

Claudia dos Santos¹, John C Marshall²

Affiliations

¹ Department of Medicine, St. Michael's Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada. Department of Critical Care Medicine and the Keenan Research Centre for Biomedical Science of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.
² Department of Critical Care Medicine and the Keenan Research Centre for Biomedical Science of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada. Department of Surgery, St. Michael's Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada. marshallj@smh.ca.

PMID: 25320231
DOI: 10.1126/scitranslmed.3010501

Comment

Bridging lipid metabolism and innate host defense

Claudia dos Santos et al. Sci Transl Med. 2014.

. 2014 Oct 15;6(258):258fs41.

doi: 10.1126/scitranslmed.3010501.

Authors

Claudia dos Santos¹, John C Marshall²

Affiliations

¹ Department of Medicine, St. Michael's Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada. Department of Critical Care Medicine and the Keenan Research Centre for Biomedical Science of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.
² Department of Critical Care Medicine and the Keenan Research Centre for Biomedical Science of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada. Department of Surgery, St. Michael's Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada. marshallj@smh.ca.

PMID: 25320231
DOI: 10.1126/scitranslmed.3010501

Abstract

Host- and pathogen-derived lipids share clearance mechanisms that pinpoint PCSK9 as a plausible target for the treatment of some patients with sepsis (Walley et al., this issue).

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Comment on

PCSK9 is a critical regulator of the innate immune response and septic shock outcome.
Walley KR, Thain KR, Russell JA, Reilly MP, Meyer NJ, Ferguson JF, Christie JD, Nakada TA, Fjell CD, Thair SA, Cirstea MS, Boyd JH. Walley KR, et al. Sci Transl Med. 2014 Oct 15;6(258):258ra143. doi: 10.1126/scitranslmed.3008782. Sci Transl Med. 2014. PMID: 25320235 Free PMC article. Clinical Trial.

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Bridging lipid metabolism and innate host defense

Affiliations

Bridging lipid metabolism and innate host defense

Authors

Affiliations

Abstract

Comment on

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Miscellaneous