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. 1989 Dec 18;259(1):61-3.
doi: 10.1016/0014-5793(89)81494-2.

Potent selective inhibitors of protein kinase C

P D Davis  1 , C H Hill, E Keech, G Lawton, J S Nixon, A D Sedgwick, J Wadsworth, D Westmacott, S E Wilkinson
Affiliations
Free article

Potent selective inhibitors of protein kinase C

P D Davis et al. FEBS Lett. .
Free article

Abstract

A series of potent, selective inhibitors of protein kinase C has been derived from the structural lead provided by the microbial broth products, staurosporine and K252a. Our inhibitors block PCK in intact cells (platelets and T cells), and prevent the proliferation of mononuclear cells in response to interleukin 2 (IL2).

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