Isotretinoin-associated Sweet's syndrome: a case report

Abstract

Objective: Sweet's syndrome (SS) is characterized by various clinical symptoms, physical features, and pathological findings. Although cases of SS are very rare, there has been an increase in the incidence of drug-induced SS. Till date, there have been only few reported cases of isotretinoin-induced SS. In this report, we describe the case of a 19-year-old girl who developed SS after systemic treatment with oral isotretinoin for nodulocystic acne.

Conclusions: The findings of this report emphasize the importance of evaluating isotretinoin as a possible, though uncommon, cause of SS and replacing it with another treatment if its involvement is suspected.

Figure 1

Isotretinoin-associated Sweet’s Syndrome. Erythematous, edematous, painful plaques on suprapubic area (A) and right lower extremity (B).

Figure 2

Isotretinoin-associated Sweet’s Syndrome. Edema of dermis, infiltration of neutrophils and leukocytoclasis, edema of endothelial cells and no vasculitis.