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Case Reports
. 2014 Dec 15;10(12):1341-2.
doi: 10.5664/jcsm.4296.

Asenapine-induced restless legs syndrome: differentiation from akathisia

W Vaughn McCall  1 , Mary Anne Riley  1 , Chelsea Hodges  1 , Laryssa McCloud  1 , Marjorie Phillips  2 , Peter B Rosenquist  1
Affiliations
Case Reports

Asenapine-induced restless legs syndrome: differentiation from akathisia

W Vaughn McCall et al. J Clin Sleep Med. .

Abstract

Akathisia and restless legs syndrome (RLS) share some common clinical features and a common relationship with dopamine dysfunction. However, the underlying causes and appropriate treatments for akathisia and RLS are different. Herein we describe a case of RLS that was precipitated by a single dose of asenapine, which is an atypical antipsychotic, and dissect the features that support the contention that this was indeed a case of RLS and not akathisia.

Keywords: akathisia; asenapine; restless leg syndrome.

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References

    1. Allen R, Picchietti D, Hening WA, et al. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology: a report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med. 2003;4:101–19. - PubMed
    1. Cervenka S, Palhagen S, Comley RA, et al. Support for dopaminergic hypoactivity in restless legs syndrome: a PET study on D2-receptor binding. Brain. 2006;129:2017–28. - PubMed
    1. American Psychiatric Association. 5th ed. Arlington, VA: American Psychiatric Association; 2013. Diagnostic and Statistical Manual of Mental Disorders.
    1. Kumar R, Sachdev PS. Akathisia and second-generation antipsychotic drugs. Curr Opin Psychiatry. 2009;22:293–9. - PubMed
    1. Benes H, Walters AS, Allen RP, et al. Definition of restless legs syndrome, how to diagnose it, and how to differentiate it from RLS mimics. Mov Disord. 2007;22:S401–8. - PubMed

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