Adverse effects of androgen-deprivation therapy in prostate cancer and their management

Abstract

Objective: To provide an up-to-date summary of current literature on the management of adverse effects of androgen-deprivation therapy (ADT).

Patients and methods: All relevant medical literature on men with prostate cancer treated with ADT from 2005 to 2014, and older relevant papers, were reviewed. Recent health advisory statements from the Australian government, societies and advocacy groups have been incorporated to the document.

Results: There are numerous adverse effects of ADT that require pro-active prevention and treatment. Ranging from cardiovascular disease, diabetes and osteoporosis, to depression, cognitive decline and sexual dysfunction, the range of adverse effects is wide. Baseline assessment, monitoring, prevention and consultation from a multidisciplinary team are important in minimising the harm from ADT.

Conclusions: This review provides a series of practical recommendations to assist with managing the adverse effects of ADT.

Keywords: adverse effect; androgen-deprivation therapy; prostate cancer.