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Review
. 2014 May;18(2):229-34.
doi: 10.4103/0973-029X.140762.

MicroRNAs - Biology and clinical applications

Kannan Ranganathan  1 , Vaishnavi Sivasankar  1
Affiliations
Review

MicroRNAs - Biology and clinical applications

Kannan Ranganathan et al. J Oral Maxillofac Pathol. 2014 May.

Abstract

MicroRNAs are a highly conserved group of small, non-coding RNA molecules, which are 19-25 nucleotides in size. Previously thought to be evolutionary debris with no evident function, these small RNAs have been found to control gene expression primarily by silencing the gene. MicroRNAs are critical to cell physiology and development. They are also implicated in pathological processes such as autoimmune diseases, viral infections and carcinogenesis.

Keywords: Gene silencing; MicroRNAs; non-coding RNAs.

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Conflict of interest statement

Conflict of Interest: None declared.

References

    1. Lodish HB, Zipursky SL, et al. 4th ed. New York: W H Freeman; 2000. Molecular Cell Biology.
    1. Condorelli G, Dimmeler S. MicroRNAs: Components of an integrated system controlling cardiac development, physiology, and disease pathogenesis. CardiovascRes. 2008;79:551–2. - PubMed
    1. Bahadori M. New Advances in RNAs. ArchIranMed. 2008;11:435–43. - PubMed
    1. Mattick JS, Makunin IV. Small regulatory RNAs in mammals. HumMolecular Genet. 2005;14:R121–32. - PubMed
    1. Kim VN, Nam JW. Genomics of microRNA. Trends Genet. 2006;22:165–73. - PubMed