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. 2014;22(5):250-5.
doi: 10.1590/1413-78522014220500978.

Correlation between the expression of vegf and survival in osteosarcoma

André Mathias Baptista  1 , André Ferrari De França Camargo  1 , Renée Zon Filippi  1 , Cláudia Regina Gomes Cardim Mendes De Oliveira  1 , Raymundo Soares De Azevedo Neto  2 , Olavo Pires De Camargo  1
Affiliations

Correlation between the expression of vegf and survival in osteosarcoma

André Mathias Baptista et al. Acta Ortop Bras. 2014.

Abstract

Objective: To present a series of 50 consecutive patients with non-metastatic extremity osteosarcoma, and attempt to correlate expression of the vascular endothelial growth factor (VEGF) protein in biopsy tissue to their prognosis regarding overall survival, disease-free survival and local recurrence.

Methods: Fifty cases of non-metastatic osteosarcoma of the extremities treated between 1986 and 2006 at Instituto de Ortopedia e Traumatologia da Universidade de São Paulo, São Paulo, Brasil, were evaluated regarding expression of the VEGF protein. There were 19 females and 31 males. The mean age was 16 years old (range 5-28 years old) and the mean follow-up was 60.6 months (range 25-167 months). The variables studied were age, gender, anatomic location, type of surgery, surgical margins, tumor size, post chemotherapy necrosis, local recurrence, pulmonary metastasis and death.

Results: Thirty-six patients showed VEGF expression on 30% or less cells (low), and the remaining 14 cases had VEGF expression above 30% (high). Among the 36 patients with low VEGF expression, nine developed pulmonary metastasis and four died (11.1%). Among the 14 patients with high VEGF expression, six developed pulmonary metastasis and three died (21.4%).

Conclusion: There was no statistically significant correlation between the expression of VEGF and any of the variables studied. Level of Evidence IV, Therapeutic Study.

Keywords: Neovascularization, pathologic; Osteosarcoma; Prognosis.

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Conflict of interest statement

All the authors declare that there is no potential conflict of interest referring to this article.

Figures

Figure 1
Figure 1. Kaplan-Meier overall survival curves for groups 1 (low VEGF expression) and 2 (high VEGF expression).
Figure 2
Figure 2. Kaplan-Meier local recurrence curves for groups 1 (low VEGF expression) and 2 (high VEGF expression).
Figure 3
Figure 3. Kaplan-Meier disease free survival curves for groups 1 (low VEGF expression) and 2 (high VEGF expression).
See this image and copyright information in PMC

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