Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Jun 29;4(4):153.
doi: 10.4172/2157-7609.1000153.

Hyperglycemia as a Risk Factor of Ischemic Stroke

Ziyan Zhang  1 , Jingqi Yan  1 , Honglian Shi  1
Affiliations

Hyperglycemia as a Risk Factor of Ischemic Stroke

Ziyan Zhang et al. J Drug Metab Toxicol. .

Abstract

Diabetes is considered a major risk factor for stroke and is associated with worsened stroke outcomes. Here, we discuss and summarize the mechanisms that have been associated with the increased risk of stroke due to the hyperglycemia in diabetes mellitus. In diabetic stroke models, hyperglycemia exaggerates the following damaging processes: acidosis, accumulation of reactive oxygen species/reactive nitrogen, inflammation and mitochondrial dysfunction. Understanding the mechanism of diabetes acting as a stroke risk factor will definitely assist to reveal issues related to drug metabolism and toxicity in diabetic stroke. In addition, it is suggested that future studies may focus on the mechanisms mediating blood-brain barrier and astrocytes dysfunction under hyperglycemic stroke.

Keywords: BBB; Diabetes; Hyperglycemia; Neuroprotection; Stroke.

PubMed Disclaimer

Figures

Scheme 1
Scheme 1
Possible mechanism of hyperglycemia-mediated increased stroke occurrence and exacerbated stroke outcome.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Weir NU, Dennis MS. Meeting the challenge of stroke. Scott Med J. 1997;42:145–147. - PubMed
    1. Caplan LR, Hon FK. Clinical diagnosis of patients with cerebrovascular disease. Prim Care. 2004;31:95–109. - PubMed
    1. Lyden PD, Zivin JA. Hemorrhagic transformation after cerebral ischemia: mechanisms and incidence. Cerebrovasc Brain Metab Rev. 1993;5:1–16. - PubMed
    1. Capes SE, Hunt D, Malmberg K, Pathak P, Gerstein HC. Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview. Stroke. 2001;32:2426–2432. - PubMed
    1. Gray CS, Hildreth AJ, Sandercock PA, O’Connell JE, Johnston DE, et al. Glucose-potassium-insulin infusions in the management of post-stroke hyperglycaemia: the UK Glucose Insulin in Stroke Trial (GIST-UK) Lancet Neurol. 2007;6:397–406. - PubMed

LinkOut - more resources