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. 2013 Jun 29;4(4):153.
doi: 10.4172/2157-7609.1000153.

Hyperglycemia as a Risk Factor of Ischemic Stroke

Ziyan Zhang  1 , Jingqi Yan  1 , Honglian Shi  1
Affiliations

Hyperglycemia as a Risk Factor of Ischemic Stroke

Ziyan Zhang et al. J Drug Metab Toxicol. .

Abstract

Diabetes is considered a major risk factor for stroke and is associated with worsened stroke outcomes. Here, we discuss and summarize the mechanisms that have been associated with the increased risk of stroke due to the hyperglycemia in diabetes mellitus. In diabetic stroke models, hyperglycemia exaggerates the following damaging processes: acidosis, accumulation of reactive oxygen species/reactive nitrogen, inflammation and mitochondrial dysfunction. Understanding the mechanism of diabetes acting as a stroke risk factor will definitely assist to reveal issues related to drug metabolism and toxicity in diabetic stroke. In addition, it is suggested that future studies may focus on the mechanisms mediating blood-brain barrier and astrocytes dysfunction under hyperglycemic stroke.

Keywords: BBB; Diabetes; Hyperglycemia; Neuroprotection; Stroke.

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Figures

Scheme 1
Scheme 1
Possible mechanism of hyperglycemia-mediated increased stroke occurrence and exacerbated stroke outcome.
See this image and copyright information in PMC

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