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Review
. 1989 Nov;10(11):375-81.
doi: 10.1016/0167-5699(89)90271-5.

The role of cell surface recognition structures in the initiation of MHC-unrestricted 'promiscuous' killing by T cells

D L Thiele, P E Lipsky
Review

The role of cell surface recognition structures in the initiation of MHC-unrestricted 'promiscuous' killing by T cells

D L Thiele et al. Immunol Today. 1989 Nov.

Abstract

CD3+ T cells mediate relatively promiscuous patterns of major histocompatibility complex (MHC)-unrestricted target cell lysis following activation. Cell-cell contact between target and effector cells is essential in this form of cytotoxicity. Although the T-cell receptor (TCR)-CD3 molecular complex can transmit signals that initiate MHC unrestricted T-cell killing, recognition of targets by the TCR is not essential for this form of cytotoxicity. In this review by Dwain Thiele and Peter Lipsky, a model of the triggering of T cells to effect MHC-unrestricted cytotoxicity is proposed.

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