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. 2015 Jan;43(Database issue):D818-24.
doi: 10.1093/nar/gku987. Epub 2014 Oct 20.

Mouse Tumor Biology (MTB): a database of mouse models for human cancer

Carol J Bult  1 , Debra M Krupke  2 , Dale A Begley  2 , Joel E Richardson  2 , Steven B Neuhauser  2 , John P Sundberg  2 , Janan T Eppig  2
Affiliations

Mouse Tumor Biology (MTB): a database of mouse models for human cancer

Carol J Bult et al. Nucleic Acids Res. 2015 Jan.

Abstract

The Mouse Tumor Biology (MTB; http://tumor.informatics.jax.org) database is a unique online compendium of mouse models for human cancer. MTB provides online access to expertly curated information on diverse mouse models for human cancer and interfaces for searching and visualizing data associated with these models. The information in MTB is designed to facilitate the selection of strains for cancer research and is a platform for mining data on tumor development and patterns of metastases. MTB curators acquire data through manual curation of peer-reviewed scientific literature and from direct submissions by researchers. Data in MTB are also obtained from other bioinformatics resources including PathBase, the Gene Expression Omnibus and ArrayExpress. Recent enhancements to MTB improve the association between mouse models and human genes commonly mutated in a variety of cancers as identified in large-scale cancer genomics studies, provide new interfaces for exploring regions of the mouse genome associated with cancer phenotypes and incorporate data and information related to Patient-Derived Xenograft models of human cancers.

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Figures

Figure 1.
Figure 1.
(A) Screenshot of MTB's Cancer QTL Viewer showing the display of all annotated cancer QTL regions for the laboratory mouse displayed in genome context. (B) Links to QTL Detail pages in the MGI database.
Figure 2.
Figure 2.
Screenshot of a subset of search results using a list of 26 human genes reported as frequently mutated in human lung adenocarcinoma in Ding et al. (43). Search results provide rapid access to (A) alleles/genotypes in different strains of mice and (B) to the types of genetic variants/alterations that have been observed for the gene in mouse tumors.
Figure 3.
Figure 3.
Examples of PDX characterization data accessed from MTB's PDX model web portal. (A) Description of the concordance of morphological features of primary patient tumor and engrafted tumors. (B) Circos plot showing integration of genomic data from PDX tumor. (C) Tumor growth characteristics of similar tumors in different PDX models. (D) Tumor growth curves from a drug response study comparing four different treatments in tumor-bearing mice.
See this image and copyright information in PMC

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