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Case Reports
. 2014 Sep;30(Suppl 1):177-9.
doi: 10.1007/s12288-013-0314-8. Epub 2014 Jan 22.

Philadelphia chromosome positive pre-T cell acute lymphoblastic leukemia: a rare case report and short review

Shailendra Prasad Verrma  1 , Tarun Kumar Dutta  1 , K V Vinod  2 , Biswajit Dubashi  3 , Kishore Kumar Ariga  2
Affiliations
Case Reports

Philadelphia chromosome positive pre-T cell acute lymphoblastic leukemia: a rare case report and short review

Shailendra Prasad Verrma et al. Indian J Hematol Blood Transfus. 2014 Sep.

Abstract

Pre-T cell acute lymphoblastic leukemia is a relatively rare leukemia. Twenty to 30 % of adult B cell leukemia cases are Philadelphia chromosome positive and it has a therapeutic and prognostic significance. Incidence and outcome of Ph+ T cell acute lymphoblastic leukemia (T cell ALL) is unknown. Only about 25 cases of de novo Ph+ T cell ALL and 44 cases of Ph+ T ALL in blastic phase of CML has been reported. Differentiation between Ph+ Pre-T ALL/LBL and T cell lymphoblastic crises of chronic myeloid leukemia may be difficult. We report a case of adult T cell ALL having Philadelphia chromosome as the cytogenetic abnormality. He was treated with acute lymphoblastic leukemia induction chemotherapy and Imatinib and achieved complete remission.

Keywords: Philadelphia chromosome positive (Ph+); T cell acute lymphoblastic leukemia (T cell ALL).

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