Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2014 Sep;30(Suppl 1):186-9.
doi: 10.1007/s12288-013-0322-8. Epub 2014 Jan 23.

A Case of AML-M2 with Sole Interstitial Deletion in 9q Without AML1-ETO/Inv 16 Rearrangement and FLT3/NPMI Mutations

G Sandhya Devi  1 , Faiq Ahmed  1 , Manasi C Mundada  1 , S Sudha Murthy  1 , Krishna Mohan Mallavarapu  2
Affiliations
Case Reports

A Case of AML-M2 with Sole Interstitial Deletion in 9q Without AML1-ETO/Inv 16 Rearrangement and FLT3/NPMI Mutations

G Sandhya Devi et al. Indian J Hematol Blood Transfus. 2014 Sep.

Abstract

Conventional/molecular cytogenetics is important in identification of genomic abnormalities, for prognostication and in risk stratification of de novo patients with acute myeloid leukemias (AML). Here we present an AML M2 case showing the sole karyotypic abnormality, the rare interstitial deletion in the long arm of chromosome 9 with the loss of segment q12-q13.

Keywords: AML-M2; CD7; Conventional cytogenetics; Del 9q.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Peripheral smear of an AML-M2 case showing blasts with Auer rods (Leishman stain, oil immersion X100)
Fig. 2
Fig. 2
The gated population of neoplastic cells showing positivity for CD13, CD33, CD34, CD45, CD117, HLA DR, with aberrant expression of CD7
Fig. 3
Fig. 3
Karyotype shows the abnormality—46,XY,del(9)(q12 q13)
See this image and copyright information in PMC

References

    1. Raimondi SC. Cytogenetics of acute leukemias. In: Pui CH, editor. Childhood leukemias. 2. New York: Cambridge University Press; 2006. pp. 235–271.
    1. Vardiman JW, Thiele J, Arber AD, Brunning RD, Borowitz MJ, Porwit A, et al. The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood. 2009;114(5):51–937. doi: 10.1182/blood-2009-03-209262. - DOI - PubMed
    1. Naeim F, Rao PN. Acute myeloid leukemia. In: Naeim F, Rao PN, Grody WW, editors. Hematopathology morphology, immunophenotype, cytogenetics, and molecular approaches. 1. Amsterdam: Elsevier; 2008. pp. 207–255.
    1. Viguie F (1998) Del (9q) solely. Atlas Genet Cytogenet Oncol Haematol. URL:http://AtlasgeneticsOncolgy.org/
    1. Peniket A, Wainscoat J, Side L, Daly S, Kusec R, Buck G, Wheatley K, Walker H, Chatters S, Harrison C, Boultwood J, Goldstone A, Burnett A. Del (9q) AML: clinical and cytological characteristics and prognostic implications. Haematology. 2005;129(2):210–220. - PubMed

Publication types

LinkOut - more resources