Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Feb;68(2):133-6.
doi: 10.1038/ja.2014.145. Epub 2014 Oct 22.

Isolation, identification and characterization of related substances in furbenicillin

Ye Tian  1 , Yan Chang  1 , Yan-Chun Feng  1 , Dou-Sheng Zhang  1 , Changqin Hu  1
Affiliations

Isolation, identification and characterization of related substances in furbenicillin

Ye Tian et al. J Antibiot (Tokyo). 2015 Feb.

Abstract

Furbenicillin is a broad-spectrum semisynthetic penicillin with strong antibacterial activity against Gram-negative bacteria. In this study, three impurities in furbenicillin, including an unknown epimer, were determined. On the basis of a complete analysis of the spectrum (MS, (1)H,(13)C, 2D NMR and CD) and the results of chemical methods, the unknown epimer impurity was identified as 10-epi-furbenicillin (impurity 1). Isolation and structure elucidation of impurity 1 was also reported here for the first time.

PubMed Disclaimer

References

    1. Magn Reson Chem. 2007 Oct;45(10):819-29 - PubMed
    1. Appl Microbiol. 1971 Apr;21(4):710-7 - PubMed
    1. Amino Acids. 2004 Dec;27(3-4):231-47 - PubMed
    1. Adv Drug Res. 1973;7:1-105 - PubMed
    1. J Org Chem. 1976 Jul 23;41(15):2561-5 - PubMed

Publication types

LinkOut - more resources