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Review
. 2014 Dec 12;289(50):34449-56.
doi: 10.1074/jbc.R114.585984. Epub 2014 Oct 21.

Protein O-GlcNAcylation and cardiovascular (patho)physiology

Susan A Marsh  1 , Helen E Collins  2 , John C Chatham  3
Affiliations
Review

Protein O-GlcNAcylation and cardiovascular (patho)physiology

Susan A Marsh et al. J Biol Chem. .

Abstract

Our understanding of the role of protein O-GlcNAcylation in the regulation of the cardiovascular system has increased rapidly in recent years. Studies have linked increased O-GlcNAc levels to glucose toxicity and diabetic complications; conversely, acute activation of O-GlcNAcylation has been shown to be cardioprotective. However, it is also increasingly evident that O-GlcNAc turnover plays a central role in the delicate regulation of the cardiovascular system. Therefore, the goals of this minireview are to summarize our current understanding of how changes in O-GlcNAcylation influence cardiovascular pathophysiology and to highlight the evidence that O-GlcNAc cycling is critical for normal function of the cardiovascular system.

Keywords: Calcium; Cardiac Hypertrophy; Cardiovascular; Epigenetics; O-Linked N-Acetylglucosamine (O-GlcNAc).

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Figures

FIGURE 1.
FIGURE 1.
Summary of the widely accepted positive and negative effects of increased O-GlcNAc levels on the heart. ER, endoplasmic reticulum; I/R, ischemia/reperfusion.
FIGURE 2.
FIGURE 2.
Overview of the wide-ranging and complex role of O-GlcNAc in regulating the cardiovascular system. HDACs, histone deacetylases.
See this image and copyright information in PMC

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