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Case Reports
. 2014 Oct 7:8:2061-4.
doi: 10.2147/OPTH.S69047. eCollection 2014.

Lacrimal gland carcinoma ex pleomorphic adenoma with chronic lymphocytic leukemia infiltration

Rita Couceiro  1 , Cláudia Loureiro  1 , Pedro Luís  2 , Dolores López-Presa  2 , Helena Proença  1 , Ana Fonseca  1 , Manuel Monteiro-Grillo  1
Affiliations
Case Reports

Lacrimal gland carcinoma ex pleomorphic adenoma with chronic lymphocytic leukemia infiltration

Rita Couceiro et al. Clin Ophthalmol. .

Abstract

Purpose: To report a rare case of lacrimal gland carcinoma ex pleomorphic adenoma (Ca ex PA) with chronic B-cell lymphocytic leukemia (B-CLL) infiltration in a patient without a previous diagnosis of B-CLL.

Patient and methods: We report a 66-year-old woman who presented with recent worsening of a long-standing right eye proptosis. Sequential orbital computed tomography imaging was performed over the course of 2 years, and biopsy specimens were analyzed.

Results: Initial computed tomography scans revealed a lacrimal gland lesion with stable dimensions for more than 1 year and no malignancy features on incisional biopsy. Subsequently, lesion volume growth and bone erosion were documented on orbital computed tomography. Lateral orbitectomy and lacrimal gland resection were performed. Pathology and immunohistochemistry detected Ca ex PA with B-CLL infiltration.

Conclusion: This case highlights the importance of persistent investigation of clinically suspicious orbital lesions. To our knowledge, this is the first description of a case of lacrimal gland Ca ex PA with B-CLL infiltration.

Keywords: chronic lymphocytic leukemia; ex pleomorphic adenoma; lacrimal gland malignancy; proptosis.

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Figures

Figure 1
Figure 1
Orbital computed tomography. Notes: (A) Coronal section. (B) Transverse section. Showing a mass lesion in the right lacrimal gland, with regular borders and internal heterogeneity, determining an inferior and medial deviation of orbital structures.
Figure 2
Figure 2
Pleomorphic adenoma with a malignant component of myoepithelial carcinoma (right inset). Notes: Peripherally, there is infiltration by chronic lymphocytic leukemia/small lymphocytic lymphoma (left inset).
See this image and copyright information in PMC

References

    1. Shields JA, Shields CL. Eyelid, Conjunctival and Orbital Tumors – An Atlas and Textbook: An Atlas and Textbook. 2nd ed. Philadelphia, PA: Lippincott Williams and Wilkins; 2008.
    1. Tovilla-Canales JL, Ball S, Olvera O, Martin FB. Diagnosis and treatment of lacrimal gland neoplasias: a better understanding of the nature of these tumors and advanced diagnostic technologies are improving management. Rev Ophthalmol. 2013 Apr 5; Epub.
    1. Hong WK, Bast RC, Hait WN, et al. Holland-Frei Cancer Medicine. 8th ed. Shelton, CT: People’s Medical Publishing House; 2010.
    1. Coelho H, Guerra M, Teixeira MA, Canelhas A, Pinto Ribeiro AC, Lima M. Bilateral orbital masses in a patient with B-cell chronic lymphocytic leukemia: a case report. Haematologica. 2007;88(4):46–47. - PubMed
    1. Rose GE, Wright JE. Pleomorphic adenoma of the lacrimal gland. Br J Ophthalmol. 1992;76(7):395–400. - PMC - PubMed

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