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. 2014 Aug 15;7(9):5997-6005.
eCollection 2014.

Expression of Yes-associated protein (YAP) in breast phyllodes tumor

Sang Kyum Kim  1 , Woo Hee Jung  1 , Ja Seung Koo  1
Affiliations

Expression of Yes-associated protein (YAP) in breast phyllodes tumor

Sang Kyum Kim et al. Int J Clin Exp Pathol. .

Abstract

This study aimed to identify expression profiles of Yes-associated protein (YAP) and its phosphorylated form (pYAP) in phyllodes tumor (PT) of human breast and verify the clinical implications. We selected PTs from the pathologic archive and reviewed the histologic features (141 benign, 27 borderline, and 15 malignant). We made tissue microarray (TMA) block from the formalin-fixed paraffin-embedded (FFPE) tissue corresponding to the representative section. Using TMA block, we performed immunohistochemical staining of YAP and pYAP. In the stromal component, expressions of YAP and pYAP were increased in borderline/malignant PT with comparison of benign PT (P = 0.002, and P < 0.001, respectively). In the epithelial component, cytoplasmic expression of YAP was highest in borderline PT (P = 0.001). Stromal YAP expression (P < 0.001) and stromal pYAP expression (P = 0.042) were associated with shorter disease-free survival (DFS) and stromal pYAP expression (P = 0.001) was associated with shorter overall survival (OS) in univariate Cox analysis. In multivariate Cox analysis, stromal YAP expression was an independent prognostic factor associated with shorter DFS (Hazard ration: 3.206, 95% CI: 1.000-10.27, P = 0.050). In conclusion, expression level of YAP in stromal component was increased along with histologic grade of PT and YAP expression in PT was related to tumor progression and poor prognosis.

Keywords: Breast; YAP; phyllodes tumor.

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Figures

Figure 1
Figure 1
Expression for YAP and pYAP according to the histologic grade of phyllodes tumor. YAP and pYAP expressions in stromal component were identified more frequently in borderline and malignant PTs.
Figure 2
Figure 2
Correlation between clinicopathologic factors and YAP/pYAP expression in phyllodes tumor.
Figure 3
Figure 3
Disease-free survival and overall survival according to the expression of YAP in phyllodes tumor (A-D) and borderline PT (E).
See this image and copyright information in PMC

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