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. 2014 Aug 15;7(9):6072-8.
eCollection 2014.

Wnt5A expression is associated with the tumor metastasis and clinical survival in cervical cancer

Li Lin  1 , Yaqiong Liu  2 , Weihua Zhao  1 , Bo Sun  1 , Qi Chen  1
Affiliations

Wnt5A expression is associated with the tumor metastasis and clinical survival in cervical cancer

Li Lin et al. Int J Clin Exp Pathol. .

Abstract

Aims: To identify the clinical significance of Wnt5A expression in the development and progression of cervical cancer.

Methods: Real-time PCR was performed in 8 pairs of surgically resected cervical cancer and adjacent normal cervical tissues. Immunohistochemistry was performed to examine Wnt5A expression in 94 paraffin-embedded cervical cancer samples. Associations of Wnt5A expression with clinicopathological factors and clinical survival were analyzed.

Results: Wnt5A expression was overexpressed in cervical cancer tissues compared with adjacent normal cervix. Wnt5A expression tended to be positively correlated with lymph nodes metastasis (P = 0.028) and recurrence (P = 0.009). Moreover, patients with higher Wnt5A expression in cancer tissues had better overall (P = 0.004) and recurrent-free survival (P = 0.012) than those with lower Wnt5A expression. Multivariate analysis revealed that Wnt5A was an independent prognostic factor (P = 0.026) for predicting overall survival of cervical cancer patients.

Conclusion: Upregulation of Wnt5A was associated with metastasis and progression of cervical cancer. The results of our study unravel the significance of Wnt/Ca2+ signaling in cervical cancer.

Keywords: Cervical cancer; Wnt/Ca2+ signaling; Wnt5A; prognosis.

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Figures

Figure 1
Figure 1
Wnt5A expression in cervical cancer specimens was detected by Real-time PCR (n = 8) compared with adjacent noncancerous tissue. asterisks, P < 0.05.
Figure 2
Figure 2
High (A, B) and low (C, D) expression of Wnt5A in cervical cancer tissues by immunohistochemistry. (A, C with 200× magnification; B, D with 400× magnification).
Figure 3
Figure 3
Kaplan-Meier curves of 94 cervical cancer patients with low versus high expression of Wnt5A.
See this image and copyright information in PMC

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