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. 2014 Jul;4(3):191-4.
doi: 10.4103/2229-5151.141352.

Comparison of the effect of intravenous ketamine and intramuscular ketamine for orthopedic procedures in children's sedation

Mehdi Momeni  1 , Mohsen Esfandbod  1 , Morteza Saeedi  1 , Mohamadreza Farnia  1 , Roya Basirani  1 , Jeyran Zebardast  1
Affiliations

Comparison of the effect of intravenous ketamine and intramuscular ketamine for orthopedic procedures in children's sedation

Mehdi Momeni et al. Int J Crit Illn Inj Sci. 2014 Jul.

Abstract

Background: Ketamine is used as a general anesthetic for short-term surgical procedures. The aim of this study is to compare the effect of intravenous (IV) ketamine and intramuscular (IM) ketamine in children admitted to the emergency department (ED).

Materials and methods: This is a clinical trial on 60 patients who were randomly classified into two groups. The first group received IV ketamine (1 mg/kg) and the second received IM ketamine (4 mg/kg). Data were collected before, during, and after the procedure. Time to reach sedation, severity of the sedation, and complications of the drug until discharge were studied.

Results: In this study, 60 patients were evaluated. The average length of the procedures was similar in both groups (P > 0.05). According to this study, sedation levels in the two groups in 5, 10, and 15 minutes did not show significant differences (P > 0.05), but there was a significant difference in sedation levels of patients in 30, 35, 40, and 45 minutes during sedation (P = 0.03, P = 0.04, P = 0.03 and P = 0.05). There was no significant difference in the incidence of complications between the two groups.

Dicussion: There was no significant difference in complications and level of sedation in both groups, but sedation was longer in the IM group; so, IV ketamine is the desirable approach for orthopedic procedures in sedating children.

Keywords: Children sedation; intramuscular ketamine; intravenous ketamine; orthopedic procedures.

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Conflict of interest statement

Conflict of Interest: No.

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References

    1. Chudnofsky CR, Lozon MM. Procedural Sedation and Analgesia. In: Marx JA, Hockberger RS, Walls RM, editors. Rosen's emergency medicine: Concepts and clinical practice. 6th ed. Philadelphia PA: Mosby; 2006. pp. 2938–55.
    1. Shah RK, Singh RP, Prasad N. Sedation with ketamine: A Safe and effective anaesthetic agent for children in the developing world. Nepal Med Coll J. 2003;5:9–13. - PubMed
    1. Karapinar B, Yilmaz D, Demirağ K, Kantar M. Sedation with ketamine and midazolam for painful procedures in children. Pediatr Int. 2006;48:146–51. - PubMed
    1. Roback MG, Wathen JE, Mackenzie T, Bajaj L. A Randomized, Controlled trial of IV versos IM Ketamine for Sedation of pediatric receiving emergency department Orthopedic procedures. Ann Emerg Med. 2006;48:605–12. - PubMed
    1. Green SM, Johnson NE. Ketamine sedation for pediatric procedures: Part 2, Review and implications. Ann Emerg Med. 1990;19:1033–46. - PubMed