The molecular machinery of neurotransmitter release (Nobel lecture)

Abstract

The most important property of synaptic transmission is its speed, which is crucial for the overall workings of the brain. In his Nobel Lecture, T. C. Südhof explains how the synaptic vesicle and the plasma membrane undergo rapid fusion during neurotransmitter release and how this process is spatially organized, such that opening of Ca(2+) -channels allows rapid translation of the entering Ca(2+) signal into a fusion event.

Keywords: hormone secretion; intracellular signaling; membrane fusion; synaptic plasticity; vesicular transport.