Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Jan 1;1(1):27-30.
doi: 10.12861/jrip.2012.10. eCollection 2012.

Association between the proportion of globally sclerotic glomeruli and various morphologic variables and clinical data of IgA nephropathy patients

Hamid Nasri  1 , Mohammad Reza Ardalan  2
Affiliations

Association between the proportion of globally sclerotic glomeruli and various morphologic variables and clinical data of IgA nephropathy patients

Hamid Nasri et al. J Renal Inj Prev. .

Abstract

Introduction: Immunoglobulin A nephropathy is the most common form of glomerular nephropathy among children and young adults.

Objectives: To evaluate the possible correlation between the extent of sclerotic glomeruli and various morphologic variables and clinical data of IgA nephropathy (IgAN) patients, we conducted an observational study, on 136 IgAN patients' biopsies.

Patients and methods: Of the 136 patients, 94 (69.1%) were male. The mean age of the patients was 37.6 ± 13.4 years. The mean of serum creatinine was 1.94±3.7 mg/dl (median=1.2mg/dl), also mean of proteinuria was 1726±1247 mg/day (median=1500 mg/day). In this study of 14.9±3.7 glomeruli in biopsies, 2.5±3.2 (median=2) were globally sclerotic.

Results: In this study we found, significant positive correlation between proportion of globally sclerotic glomeruli and serum creatinine, amount of proteinuria, and also quantity of tubulointerstitial fibrosis. Also, in this study, the association of proportion of globally sclerotic glomeruli with M, E, S and T variables of Oxford classification was significantly positive.

Conclusion: We propose firstly that, sclerotic glomeruli reported routinely in the pathology reports of IgA nephropathy patients and secondly we suggest further investigations to possible inclusion of other morphologic variables like proportion of sclerotic glomeruli to Oxford classification of IgAN to widen the scope of this classification.

Keywords: Immunoglobulin A nephropathy; Oxford classification; Sclerotic glomeruli.

PubMed Disclaimer

References

    1. Julian BA, Waldo FB, Rifai A, Mesteckey J. IgA nephropathy, the most common glomerulonephritis worldwide: a neglected disease in the United States? Am J Med. 1988;84:129–32. - PubMed
    1. Koyama A, Igarashi M, Kobayashi M. Natural history and risk factors for immunoglobulin A nephropathy in JapanResearch Group on Progressive Renal Diseases. Am J Kidney Dis. 1997;29:526–32. - PubMed
    1. Coppo R, Troyanov S, Camilla R, Hogg RJ, Cattran DC, Cook HT. et al. The Oxford IgA nephropathy clinicopathological classification is valid for children as well as adults. Kidney Int. 2010;77:921–7. - PubMed
    1. Roberts IS, Cook HT, Troyanov S, Alpers CE, Amore A, Barratt J. et al. The Oxford classification of IgA nephropathy: pathology definitions, correlations, and reproducibility. Kidney Int. 2009;76:546–56. - PubMed
    1. Bartosik LP, Lajoie G, Sugar L, Cattran DC. Predicting progression in IgA nephropathy. Am J Kidney Dis. 2001;38:728–35. - PubMed

LinkOut - more resources