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Review
. 2015:66:97-110.
doi: 10.1146/annurev-med-051013-052304. Epub 2014 Oct 9.

Regulation of tumor metastasis by myeloid-derived suppressor cells

Thomas Condamine  1 , Indu Ramachandran, Je-In Youn, Dmitry I Gabrilovich
Affiliations
Review

Regulation of tumor metastasis by myeloid-derived suppressor cells

Thomas Condamine et al. Annu Rev Med. 2015.

Abstract

Accumulation of pathologically activated immature myeloid cells with potent immune-suppressive activity is one of the major immunological hallmarks of cancer. In recent years, it became clear that in addition to their immune-suppressive activity, myeloid-derived suppressor cells (MDSCs) influence tumor progression in a variety of ways. They are directly implicated in the promotion of tumor metastases by participating in the formation of premetastatic niches, promoting angiogenesis and tumor cell invasion. In this review, we discuss recent data describing various roles of MDSCs in the formation of tumor metastases.

Keywords: angiogenesis; chemotherapy; immune suppression; tumor cell invasion.

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Figures

Figure 1
Figure 1. Effect of MDSC on angiogenesis
MDSC are recruited to the tumor site by several chemokines and in tumor microenvironment produce number of soluble factors promoting angiogenesis.
Figure 2
Figure 2
Contribution of MDSC to the formation of pre-metastatic niche
See this image and copyright information in PMC

References

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