Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015:66:97-110.
doi: 10.1146/annurev-med-051013-052304. Epub 2014 Oct 9.

Regulation of tumor metastasis by myeloid-derived suppressor cells

Thomas Condamine  1 , Indu Ramachandran, Je-In Youn, Dmitry I Gabrilovich
Affiliations
Review

Regulation of tumor metastasis by myeloid-derived suppressor cells

Thomas Condamine et al. Annu Rev Med. 2015.

Abstract

Accumulation of pathologically activated immature myeloid cells with potent immune-suppressive activity is one of the major immunological hallmarks of cancer. In recent years, it became clear that in addition to their immune-suppressive activity, myeloid-derived suppressor cells (MDSCs) influence tumor progression in a variety of ways. They are directly implicated in the promotion of tumor metastases by participating in the formation of premetastatic niches, promoting angiogenesis and tumor cell invasion. In this review, we discuss recent data describing various roles of MDSCs in the formation of tumor metastases.

Keywords: angiogenesis; chemotherapy; immune suppression; tumor cell invasion.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Effect of MDSC on angiogenesis
MDSC are recruited to the tumor site by several chemokines and in tumor microenvironment produce number of soluble factors promoting angiogenesis.
Figure 2
Figure 2
Contribution of MDSC to the formation of pre-metastatic niche
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Gabrilovich DI, Ostrand-Rosenberg S, Bronte V. Coordinated regulation of myeloid cells by tumours. Nat Rev Immunol. 2012;12:253–68. - PMC - PubMed
    1. Talmadge JE, Gabrilovich DI. History of myeloid-derived suppressor cells. Nature reviews. Cancer. 2013;13:739–52. - PMC - PubMed
    1. Youn JI, Gabrilovich DI. The biology of myeloid-derived suppressor cells: the blessing and the curse of morphological and functional heterogeneity. Eur J Immunol. 2010;40:2969–75. - PMC - PubMed
    1. Gabrilovich DI, Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol. 2009;9:162–74. - PMC - PubMed
    1. Youn JI, Nagaraj S, Collazo M, Gabrilovich DI. Subsets of myeloid-derived suppressor cells in tumor-bearing mice. J Immunol. 2008;181:5791–802. - PMC - PubMed

Publication types

MeSH terms