Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2014 Nov 7;9(11):1829-31.
doi: 10.2215/CJN.09620914. Epub 2014 Oct 23.

Circulating complement levels and C3 glomerulopathy

Fernando C Fervenza  1 , Sanjeev Sethi  2
Affiliations
Editorial

Circulating complement levels and C3 glomerulopathy

Fernando C Fervenza et al. Clin J Am Soc Nephrol. .
No abstract available

Keywords: GN; complement; nephritis.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Electron microscopy spectrum in C3 glomerulopathy. Electron microscopy of a single glomerulus showing features of C3GN with mesangial and capillary wall electron dense deposits in some capillary loops (A), and features of DDD with dense intramembranous deposits in other capillary loops. (B) Thin black arrow points to discrete mesangial and capillary wall deposits typical of C3GN, and thick arrows points to dense intramembranous deposits typical of DDD. Original magnification, ×4700 in A; ×6800 in B.
See this image and copyright information in PMC

Comment on

  • Defining the complement biomarker profile of C3 glomerulopathy.
    Zhang Y, Nester CM, Martin B, Skjoedt MO, Meyer NC, Shao D, Borsa N, Palarasah Y, Smith RJ. Zhang Y, et al. Clin J Am Soc Nephrol. 2014 Nov 7;9(11):1876-82. doi: 10.2215/CJN.01820214. Epub 2014 Oct 23. Clin J Am Soc Nephrol. 2014. PMID: 25341722 Free PMC article.

References

    1. Noris M, Remuzzi G: Overview of complement activation and regulation. Semin Nephrol 33: 479–492, 2013 - PMC - PubMed
    1. Thurman JM, Holers VM: The central role of the alternative complement pathway in human disease. J Immunol 176: 1305–1310, 2006 - PubMed
    1. Zipfel PF, Skerka C: Complement regulators and inhibitory proteins. Nat Rev Immunol 9: 729–740, 2009 - PubMed
    1. Ferreira VP, Pangburn MK, Cortés C: Complement control protein factor H: The good, the bad, and the inadequate. Mol Immunol 47: 2187–2197, 2010 - PMC - PubMed
    1. Zipfel PF, Smith RJH, Skerka C: Factor I and factor H deficiency in renal diseases: similar defects in the fluid phase have a different outcome at the surface of the glomerular basement membrane. Nephrol Dial Transplant 24: 385–387, 2009 - PMC - PubMed