Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2014 May;3(2):52-6.
doi: 10.5582/irdr.2014.01005.

Seizures caused by pyridoxine (vitamin B6) deficiency in adults: A case report and literature review

Yisha Tong  1
Affiliations
Case Reports

Seizures caused by pyridoxine (vitamin B6) deficiency in adults: A case report and literature review

Yisha Tong. Intractable Rare Dis Res. 2014 May.

Abstract

Pyridoxine (vitamin B6) deficiency is a recognised cause of intractable seizures in neonates. However, pyridoxine deficiency related seizures in adults were rarely reported. This article reports a case of a 79 year old lady who suffered from new-onset seizures and was successfully treated with vitamin B6. The patient had chronic renal disease and weight loss due to anepithymia following a pelvic fracture. This article also reviews literatures of seizures caused by pyridoxine deficiency in adults. Seizures caused by vitamin B6 deficiency in adults may result from dietary deficiency, liver disease, pregnancy and certain medications and can be easily treated by vitamin B6 with excellent outcome. Clinicians should consider vitamin B6 deficiency as a potential aetiology of seizures, even in patients who suffer from other underlying diseases which can cause seizures.

Keywords: Adult; literature review; pyridoxine; seizure; vitamin B6.

PubMed Disclaimer

References

    1. Hunt AD, Jr, Stokes J, Jr, McCrory WW, Stroud HH. Pyridoxine dependency: Report of a case of intractable convulsions in an infant controlled by pyridoxine. Pediatrics. 1954; 13:140-145 - PubMed
    1. Baxter P. Pyridoxine dependent and pyridoxine responsive seizures. In: Baxter P, ed. Vitamin Responsive Conditions in Paediatric Neurology. London: MacKeith Press, 2001:109-165
    1. Asnis DS, Bhat JG, Melchert AF. Reversible seizures and mental status changes in a dialysis patient on isoniazid preventive therapy. Ann Pharmacother. 1993; 27:444-446 - PubMed
    1. Schulze-Bonhage A, Kurthen M, Walger P, Elger CE. Pharmacorefractory status epilepticus due to low vitamin B6 levels during pregnancy. Epilepsia. 2004; 45:81-84 - PubMed
    1. Tajender V, Saluja J. INH induced status epilepticus: Response to pyridoxine. Indian J Chest Dis Allied Sci. 2006; 48:205-206 - PubMed

Publication types

LinkOut - more resources