Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2014 Oct 28:4:6791.
doi: 10.1038/srep06791.

Association of BRCA2 N372H polymorphism with cancer susceptibility: a comprehensive review and meta-analysis

Wen-Qiong Xue  1 , Yong-Qiao He  1 , Jin-Hong Zhu  2 , Jian-Qun Ma  3 , Jing He  1 , Wei-Hua Jia  1
Affiliations
Meta-Analysis

Association of BRCA2 N372H polymorphism with cancer susceptibility: a comprehensive review and meta-analysis

Wen-Qiong Xue et al. Sci Rep. .

Abstract

BRCA2 gene plays an important role in homologous recombination. Polymorphic variants in this gene has been suggested to confer cancer susceptibility. Numerous studies have investigated association between BRCA2 N372H polymorphism and risk of several cancers, especially breast cancer. However, the results were inconsistent. We performed a comprehensive meta-analysis to provide a more precise assessment of the association between N372H and cancer risk, following the latest meta-analysis guidelines (PRISMA). Forty six studies involving 36299 cases and 48483 controls were included in our meta-analysis. The crude ORs and the 95% CIs were used to evaluate the strength of the association. The results indicated that the BRCA2 N372H variant was significantly associated with an increased risk of overall cancer (dominant model: OR = 1.07, 95% CI = 1.01-1.13; recessive model: OR = 1.12, 95% CI = 1.02-1.23). Moreover, stratified analyses by the cancer type and source of control observed significantly increased risk associated with BRCA2 N372H in subgroups with ovarian cancer, non-Hodgkin lymphoma and population-based controls, but not breast cancer or hospital-based controls. We also found such association among Africans. Overall, the meta-analysis suggested that BRCA2 N372H may be a cancer susceptibility polymorphism. Well-designed and large-scale studies are needed to substantiate the association between BRCA2 N372H polymorphism and cancer risk.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Flow chat of the study screening process in this meta-analysis.
Figure 2
Figure 2. Forest plot of the association between BRCA2 N372H and cancer risk under homozygous model.
For each study, the estimation of OR and its 95% CI are plotted with a box and a horizontal line. formula image, pooled ORs and its 95% CIs.
Figure 3
Figure 3. Forest plot of the association between BRCA2 N372H and cancer risk among control source analysis under homozygous model.
For each study, the estimation of OR and its 95% CI are plotted with a box and a horizontal line. formula image, pooled ORs and its 95% CIs.
Figure 4
Figure 4. Funnel plot analysis to detect publication bias for BRCA2 N372H polymorphism by recessive model for overall analysis.
Each point represents a separate study for the indicated association.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Wood R. D., Mitchell M., Sgouros J. & Lindahl T. Human DNA repair genes. Science 291, 1284–9 (2001). - PubMed
    1. Christmann M., Tomicic M. T., Roos W. P. & Kaina B. Mechanisms of human DNA repair: an update. Toxicology 193, 3–34 (2003). - PubMed
    1. Jackson S. P. Sensing and repairing DNA double-strand breaks. Carcinogenesis 23, 687–96 (2002). - PubMed
    1. Pierce A. J. et al. Double-strand breaks and tumorigenesis. Trends Cell Biol 11, S52–9 (2001). - PubMed
    1. Lord C. J. & Ashworth A. RAD51, BRCA2 and DNA repair: a partial resolution. Nat Struct Mol Biol 14, 461–2 (2007). - PubMed

Publication types