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Comparative Study
. 2014 Oct;157(6):735-7.
doi: 10.1007/s10517-014-2655-1. Epub 2014 Oct 29.

Comparison of pharmacokinetics and relative bioavailability of tablets and substance of new dipeptide neuroleptic dilept

R V Shevchenko  1 , A A Litvin, G B Kolyvanov, V P Zherdev, V V Smirnov
Affiliations
Comparative Study

Comparison of pharmacokinetics and relative bioavailability of tablets and substance of new dipeptide neuroleptic dilept

R V Shevchenko et al. Bull Exp Biol Med. 2014 Oct.

Abstract

We studied pharmacokinetics of dilept after single cross-administration of tablets and substance of dilept in a dose of 40 mg to rabbits. The following pharmacokinetic parameters were calculated: maximum plasma concentration of dilept, time to maximum observed concentration, area under the pharmacokinetic curve, elimination half-life, and relative bioavailability. Dilept concentration in blood plasma was estimated using ultra-fast liquid chromatography with mass spectrometry detection. Relative bioavailability of dilept tablets was 93.46±28.91% of that for the substance.

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