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Review
. 2014 Nov;18(6):371-8.
doi: 10.2310/7750.2014.13191.

Network Meta-analysis of Treatments for Chronic Plaque Psoriasis in Canada

Aditya K Gupta, Deanne Daigle, Danika C A Lyons
Review

Network Meta-analysis of Treatments for Chronic Plaque Psoriasis in Canada

Aditya K Gupta et al. J Cutan Med Surg. 2014 Nov.

Abstract

Background: Psoriasis affects approximately 500,000 Canadians. Eight treatments are currently licensed for chronic plaque psoriasis in Canada.

Objective: To compare the efficacy of systemic treatments for chronic plaque psoriasis for the outcome > 75% reduction in the Psoriasis Area and Severity Index (PASI) using network meta-analysis.

Methods: PubMed and clinicaltrials.gov databases were searched up until October 15, 2013, for phase III clinical trials. A consistency model based on a random-effects bayesian statistical framework was used to compare the rates of > 75% PASI reduction across trials.

Results: Twenty-one studies were included in the network analysis. Infliximab had significantly greater odds of producing > 75% reduction in the PASI compared to all treatments. All treatments conferred greater odds of > 75% PASI reduction compared to placebo.

Conclusion: Although infliximab had the highest efficacy relative to other systemic treatments for psoriasis, adverse effects, cost, and patient preferences should also be considered when deciding on treatment.

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