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Randomized Controlled Trial
. 2014 Oct 28:12:290.
doi: 10.1186/s12967-014-0290-2.

A randomised translational trial of lifestyle intervention using a 3-tier shared care approach on pregnancy outcomes in Chinese women with gestational diabetes mellitus but without diabetes

Xilin Yang, Huiguang Tian, Fuxia Zhang, Cuiping Zhang, Yi Li, Junhong Leng, Leishen Wang, Gongshu Liu, Ling Dong, Zhijie Yu, Gang Hu, Juliana Cn Chan
Randomized Controlled Trial

A randomised translational trial of lifestyle intervention using a 3-tier shared care approach on pregnancy outcomes in Chinese women with gestational diabetes mellitus but without diabetes

Xilin Yang et al. J Transl Med. .

Erratum in

Abstract

Background: There are no randomised controlled trials to demonstrate whether lifestyle modifications can improve pregnancy outcomes of gestational diabetes mellitus (GDM) diagnosed by the International Association of Diabetes and Pregnancy Study Group's (IADPSG) criteria. We tested the effectiveness of lifestyle modifications implemented in a 3-tier's shared care (SC) on pregnancy outcomes of GDM.

Methods: Between December 2010 and October 2012, we randomly assigned 700 women with IADPSG-defined GDM but without diabetes at 26.3 (interquartile range: 25.4-27.3) gestational weeks in Tianjin, China, to receive SC or usual care (UC). The SC group received individual consultations and group sessions and performed regular self-monitoring of blood glucose compared to one hospital-based education session in the UC group. The outcomes were macrosomia defined as birth weight ≥ 4.0 kg and the pregnancy-induced hypertension (PIH).

Results: Women in the SC (n = 339) and UC (n = 361) groups delivered their infants at similar gestational weeks. Birth weight of infants in the SC group was lower than that in the UC group (3469 vs. 3371 grams, P = 0.021). The rate of macrosomia was 11.2% (38/339) in the SC group compared to 17.5% (63/361) in the UC group with relative risk (RR) of 0.64 (95% CI: 0.44-0.93). The rate of PIH was 8.0% (27/339) in the SC compared to 4.4% (16/361) in the UC with RR of 1.80 (0.99-3.28). Apgar score at 1 min < 7 was lower but preeclampsia was higher in the SC than in the UC.

Conclusions: Lifestyle modifications using a SC system improved pregnancy outcomes in Chinese women with GDM.

Trial registration: Clinicaltrials.gov; NCT01565564.

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Figures

Figure 1
Figure 1
Patient flow diagram.
See this image and copyright information in PMC

References

    1. Yang X, Hsu-Hage B, Zhang H, Zhang C, Zhang Y, Zhang C. Women with impaired glucose tolerance during pregnancy have significantly poor pregnancy outcomes. Diabetes Care. 2002;25:1619–1624. doi: 10.2337/diacare.25.9.1619. - DOI - PubMed
    1. Rosenberg TJ, Garbers S, Lipkind H, Chiasson MA. Maternal obesity and diabetes as risk factors for adverse pregnancy outcomes: differences among 4 racial/ethnic groups. Am J Public Health. 2005;95:1545–1551. doi: 10.2105/AJPH.2005.065680. - DOI - PMC - PubMed
    1. Weiner CP. Effect of varying degrees of "normal" glucose metabolism on maternal and perinatal outcome. Am J Obstet Gynecol. 1988;159:862–870. doi: 10.1016/S0002-9378(88)80156-X. - DOI - PubMed
    1. Hod M, Merlob P, Friedman S, Schoenfeld A, Ovadia J. Gestational diabetes mellitus. A survey of perinatal complications in the 1980s. Diabetes. 1991;40:74–78. doi: 10.2337/diab.40.2.S74. - DOI - PubMed
    1. Maresh M, Beard RW, Bray CS, Elkeles RS, Wadsworth J. Factors predisposing to and outcome of gestational diabetes. Obstet Gynecol. 1989;74:342–346. - PubMed

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