Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort

J Ose¹, R T Fortner¹, H Schock¹, P H Peeters², N C Onland-Moret², H B Bueno-de-Mesquita³, E Weiderpass⁴, I T Gram⁵, K Overvad⁶, A Tjonneland⁷, L Dossus⁸, A Fournier⁸, L Baglietto⁹, A Trichopoulou¹⁰, V Benetou¹¹, D Trichopoulos¹², H Boeing¹³, G Masala¹⁴, V Krogh¹⁵, A Matiello¹⁶, R Tumino¹⁷, M Popovic¹⁸, M Obón-Santacana¹⁹, N Larrañaga²⁰, E Ardanaz²¹, M-J Sánchez²², V Menéndez²³, M-D Chirlaque²⁴, R C Travis²⁵, K-T Khaw²⁶, J Brändstedt²⁷, A Idahl²⁸, E Lundin²⁹, S Rinaldi³⁰, E Kuhn³⁰, I Romieu³⁰, M J Gunter³¹, M A Merritt³¹, E Riboli³¹, R Kaaks¹

Affiliations

¹ Division of Cancer Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany.
² Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 Utrecht, The Netherlands.
³ 1] National Institute for Public Health and the Environment (RIVM), 3720 Bilthoven, The Netherlands [2] Department of Gastroenterology and Hepatology, University Medical Centre, 3542 Utrecht, The Netherlands [3] Department of Epidemiology and Statistics, the School of Public Health, Imperial College London, SW72AZ London, UK.
⁴ 1] Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, 90109 Tromsø, Norway [2] Cancer Registry of Norway, 0304 Oslo, Norway [3] Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden [4] Department of Genetic Epidemiology, Folkhälsan Research Center, 00014 Helsinki, Finland.
⁵ Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, 9037 Tromsø, Norway.
⁶ Department of Public Health, Section for Epidemiology, Aarhus University, 8000 Aarhus, Denmark.
⁷ Institute of Cancer Epidemiology, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark.
⁸ 1] Inserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women's Health team, F-94805 Villejuif, France [2] Univ Paris Sud, UMRS 1018, F-94805 Villejuif, France [3] IGR, F-94805 Villejuif, France.
⁹ 1] Cancer Epidemiology Centre, Cancer Council of Victoria, Melbourne, 3004 Victoria, Australia [2] Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, 3004 Victoria, Australia.
¹⁰ 1] Bureau of Epidemiologic Research, Academy of Athens, 23 Alexandroupoleos Street, Athens GR-115 27, Greece [2] Hellenic Health Foundation, 13 Kaisareias Street, Athens GR-115 27, Greece.
¹¹ 1] Hellenic Health Foundation, 13 Kaisareias Street, Athens GR-115 27, Greece [2] Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, 75M Asias Street, Goudi, Athens GR-115 27, Greece.
¹² 1] Bureau of Epidemiologic Research, Academy of Athens, 23 Alexandroupoleos Street, Athens GR-115 27, Greece [2] Hellenic Health Foundation, 13 Kaisareias Street, Athens GR-115 27, Greece [3] Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA.
¹³ Department of Epidemiology, German Institute of Human Nutrition (DIfE) 14558 Potsdam-Rehbrücke, Nuthetal, Germany.
¹⁴ Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute-ISPO, 50139 Florence, Italy.
¹⁵ Epidemiology and Prevention Unit, Fondazione IRCCS Instituto Nazionale dei Tumori, Via Veneziani 1, 20133 Milano, Italy.
¹⁶ Department of Clinical and Experimental Medicine, Federico II University, 80131 Naples, Italy.
¹⁷ Cancer Registry and Histopathology Unit, 'Civic - M.P. Arezzo' Hospita, ASP 97100 Ragusa, Italy.
¹⁸ Unit of Cancer Epidemiology, AO Citta' della Salute e della Scienza, Department of Medical Sciences, University of Turin and Center for Cancer Prevention (CPO-Piemonte), 10126 Turin, Italy.
¹⁹ Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), 08908 Barcelona, Spain.
²⁰ 1] Public Health Division of Gipuzkoa-BIODonostia Research Institute, Basque Regional Health Department, 20013 San Sebastian, Spain [2] Consortium for Biomedical Research in Epidemiology and Public Health (CIBER), 28029 Madrid, Spain.
²¹ 1] Consortium for Biomedical Research in Epidemiology and Public Health (CIBER), 28029 Madrid, Spain [2] Navarre Public Health Institute, 31006 Pamplona, Spain.
²² 1] Consortium for Biomedical Research in Epidemiology and Public Health (CIBER), 28029 Madrid, Spain [2] Andalusian School of Public Health, 18011 Granada, Spain.
²³ Public Health Directorate, 33006 Asturias, Spain.
²⁴ 1] Consortium for Biomedical Research in Epidemiology and Public Health (CIBER), 28029 Madrid, Spain [2] Department of Epidemiology, Murcia Regional Health Authority, 30008 Murcia, Spain.
²⁵ Cancer Epidemiology Unit, University of Oxford, OX30NR Oxford, UK.
²⁶ Department of Public Health and Primary Care, University of Cambridge, CB22QQ Cambridge, UK.
²⁷ Medical Department of Surgery, Malmö University Hospital, 20502 Malmö, Sweden.
²⁸ Department of Clinical Sciences, Obstetrics and Gynecology and Department of Public Health and Clinical Medicine, Nutritional Research Umeå University, 90185 Umeå, Sweden.
²⁹ Department of Medical Biosciences, Pathology Umeå University, 90185 Umeå, Sweden.
³⁰ International Agency for Research on Cancer, 69372 Lyon, France.
³¹ Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, SW72AZ London, UK.

PMID: 25349976
PMCID: PMC4453611
DOI: 10.1038/bjc.2014.566

Multicenter Study

Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort

J Ose et al. Br J Cancer. 2015.

. 2015 Jan 6;112(1):162-6.

doi: 10.1038/bjc.2014.566. Epub 2014 Nov 4.

Authors

Affiliations

¹ Division of Cancer Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany.
² Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 Utrecht, The Netherlands.
³ 1] National Institute for Public Health and the Environment (RIVM), 3720 Bilthoven, The Netherlands [2] Department of Gastroenterology and Hepatology, University Medical Centre, 3542 Utrecht, The Netherlands [3] Department of Epidemiology and Statistics, the School of Public Health, Imperial College London, SW72AZ London, UK.
⁴ 1] Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, 90109 Tromsø, Norway [2] Cancer Registry of Norway, 0304 Oslo, Norway [3] Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden [4] Department of Genetic Epidemiology, Folkhälsan Research Center, 00014 Helsinki, Finland.
⁵ Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, 9037 Tromsø, Norway.
⁶ Department of Public Health, Section for Epidemiology, Aarhus University, 8000 Aarhus, Denmark.
⁷ Institute of Cancer Epidemiology, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark.
⁸ 1] Inserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women's Health team, F-94805 Villejuif, France [2] Univ Paris Sud, UMRS 1018, F-94805 Villejuif, France [3] IGR, F-94805 Villejuif, France.
⁹ 1] Cancer Epidemiology Centre, Cancer Council of Victoria, Melbourne, 3004 Victoria, Australia [2] Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, 3004 Victoria, Australia.
¹⁰ 1] Bureau of Epidemiologic Research, Academy of Athens, 23 Alexandroupoleos Street, Athens GR-115 27, Greece [2] Hellenic Health Foundation, 13 Kaisareias Street, Athens GR-115 27, Greece.
¹¹ 1] Hellenic Health Foundation, 13 Kaisareias Street, Athens GR-115 27, Greece [2] Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, 75M Asias Street, Goudi, Athens GR-115 27, Greece.
¹² 1] Bureau of Epidemiologic Research, Academy of Athens, 23 Alexandroupoleos Street, Athens GR-115 27, Greece [2] Hellenic Health Foundation, 13 Kaisareias Street, Athens GR-115 27, Greece [3] Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA.
¹³ Department of Epidemiology, German Institute of Human Nutrition (DIfE) 14558 Potsdam-Rehbrücke, Nuthetal, Germany.
¹⁴ Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute-ISPO, 50139 Florence, Italy.
¹⁵ Epidemiology and Prevention Unit, Fondazione IRCCS Instituto Nazionale dei Tumori, Via Veneziani 1, 20133 Milano, Italy.
¹⁶ Department of Clinical and Experimental Medicine, Federico II University, 80131 Naples, Italy.
¹⁷ Cancer Registry and Histopathology Unit, 'Civic - M.P. Arezzo' Hospita, ASP 97100 Ragusa, Italy.
¹⁸ Unit of Cancer Epidemiology, AO Citta' della Salute e della Scienza, Department of Medical Sciences, University of Turin and Center for Cancer Prevention (CPO-Piemonte), 10126 Turin, Italy.
¹⁹ Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), 08908 Barcelona, Spain.
²⁰ 1] Public Health Division of Gipuzkoa-BIODonostia Research Institute, Basque Regional Health Department, 20013 San Sebastian, Spain [2] Consortium for Biomedical Research in Epidemiology and Public Health (CIBER), 28029 Madrid, Spain.
²¹ 1] Consortium for Biomedical Research in Epidemiology and Public Health (CIBER), 28029 Madrid, Spain [2] Navarre Public Health Institute, 31006 Pamplona, Spain.
²² 1] Consortium for Biomedical Research in Epidemiology and Public Health (CIBER), 28029 Madrid, Spain [2] Andalusian School of Public Health, 18011 Granada, Spain.
²³ Public Health Directorate, 33006 Asturias, Spain.
²⁴ 1] Consortium for Biomedical Research in Epidemiology and Public Health (CIBER), 28029 Madrid, Spain [2] Department of Epidemiology, Murcia Regional Health Authority, 30008 Murcia, Spain.
²⁵ Cancer Epidemiology Unit, University of Oxford, OX30NR Oxford, UK.
²⁶ Department of Public Health and Primary Care, University of Cambridge, CB22QQ Cambridge, UK.
²⁷ Medical Department of Surgery, Malmö University Hospital, 20502 Malmö, Sweden.
²⁸ Department of Clinical Sciences, Obstetrics and Gynecology and Department of Public Health and Clinical Medicine, Nutritional Research Umeå University, 90185 Umeå, Sweden.
²⁹ Department of Medical Biosciences, Pathology Umeå University, 90185 Umeå, Sweden.
³⁰ International Agency for Research on Cancer, 69372 Lyon, France.
³¹ Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, SW72AZ London, UK.

PMID: 25349976
PMCID: PMC4453611
DOI: 10.1038/bjc.2014.566

Abstract

Background: Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest risk associations vary by tumour characteristics.

Methods: We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n=565 cases). Multivariable conditional logistic regression models were used to estimate associations.

Results: We observed no association between IGF-I and EOC overall or by tumour characteristics.

Conclusions: In the largest prospective study to date was no association between IGF-I and EOC risk. Pre-diagnostic serum IGF-I concentrations may not influence EOC risk.

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References

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Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort

Affiliations

Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort

Authors

Affiliations

Abstract

References

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Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical