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Editorial
. 2015 Jan;65(1):34-5.
doi: 10.1161/HYPERTENSIONAHA.114.04204. Epub 2014 Oct 27.

Prospects for droxidopa in neurogenic orthostatic hypotension

Amanda J Ross  1 , Julian M Stewart  2
Affiliations
Editorial

Prospects for droxidopa in neurogenic orthostatic hypotension

Amanda J Ross et al. Hypertension. 2015 Jan.
No abstract available

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Figures

Figure
Figure
Possible mechanisms for droxidopa. Droxidopa can be metabolized into norepinephrine and epinephrine that can bind to α- and β-adrenergic receptors and have various physiological effects depending on the tissue and receptor subtype activated.
See this image and copyright information in PMC

Comment on

References

    1. Freeman R, Wieling W, Axelrod FB, et al. Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Clin Auton Res. 2011;21:69–72. - PubMed
    1. Goldstein DS, Sharabi Y. Neurogenic orthostatic hypotension: a pathophysiological approach. Circulation. 2009;119:139–146. - PMC - PubMed
    1. Biaggioni I, Freeman R, Mathias CJ, Low P, Hewitt LA, Kaufmann H on behalf of Droxidopa 302 Investigators. Randomized withdrawal study of patients with symptomatic neurogenic orthostatic hypotension responsive to droxidopa. 2014;65:XXX–XXX. - PMC - PubMed
    1. Low PA, Gilden JL, Freeman R, Sheng KN, McElligott MA. Efficacy of midodrine vs placebo in neurogenic orthostatic hypotension. A randomized, double-blind multicenter study. Midodrine Study Group. JAMA. 1997;277:1046–1051. - PubMed
    1. Man in ‘t Veld AJ, Boomsma F, van den Meiracker AH, Schalekamp MA. Effect of unnatural noradrenaline precursor on sympathetic control and orthostatic hypotension in dopamine-beta-hydroxylase deficiency. Lancet. 1987;2:1172–1175. - PubMed