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. 2014 Oct 15;24(3):383-9.
doi: 10.11613/BM.2014.041. eCollection 2014.

Ischemia modified albumin is an indicator of oxidative stress in multiple sclerosis

Ozgur Aydin  1 , Hamit Yasar Ellidag  2 , Esin Eren  3 , Fatma Kurtulus  4 , Aylin Yaman  4 , Necat Yılmaz  2
Affiliations

Ischemia modified albumin is an indicator of oxidative stress in multiple sclerosis

Ozgur Aydin et al. Biochem Med (Zagreb). .

Abstract

Introduction: Oligodendrocytes need iron in processes of energy generation and myelination. However, excessive levels of iron may exert iron induced oxidative stress and thus lead to tissue degeneration. Monitoring oxidative stress will be of paramount importance in follow-up of patients with many diseases including multiple sclerosis (MS). The aim of this study was to measure total anti-oxidative status (TAS), total oxidative status (TOS) and ischemia modified albumin (IMA) in stable relapse remitting MS (RRMS) patients.

Materials and methods: Thirty-five RRMS patients (15 males and 20 females; median age 42 (20-55) years) and thirty-five age-sex matched healthy controls (13 males and 22 females; median age 37 (21-60) years) were included in this study. All patients were diagnosed with MS according to the criteria of McDonald.

Results: IMA levels were significantly higher in RRMS patients (P < 0.001), while TAS and TOS did not show any significant difference between groups (P = 0.870 and P = 0.460, respectively).

Conclusions: Our results suggest IMA as a more efficient serum marker than TAS and TOS in detecting the oxidative stress in MS patients. Serum oxidative stress markers should be included in future study protocols besides clinical and radiological parameters.

Keywords: ischemia-modified albumin; multiple sclerosis; oxidative stress.

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Figures

Figure 1.
Figure 1.
IMA levels were significantly higher in RRMS group than the controls (left). The difference was much more prominent after IMA values were divided by the individuals albumin value to maintain a rate, namely IMA rate (IMAR) (right).
See this image and copyright information in PMC

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