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Comment
. 2014 Nov;46(11):1155-7.
doi: 10.1038/ng.3125.

SPRTN is a new player in an old story

Kevin Hiom  1
Affiliations
Comment

SPRTN is a new player in an old story

Kevin Hiom. Nat Genet. 2014 Nov.

Erratum in

  • Nat Genet. 2015 Jan;47(1):97

Abstract

A new study identifies rare mutations in SPRTN that cause a novel progeroid syndrome. The results point to an unexpected function of SPRTN and bring insight to the mechanisms that link premature aging and cancer.

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Comment on

  • Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features.
    Lessel D, Vaz B, Halder S, Lockhart PJ, Marinovic-Terzic I, Lopez-Mosqueda J, Philipp M, Sim JC, Smith KR, Oehler J, Cabrera E, Freire R, Pope K, Nahid A, Norris F, Leventer RJ, Delatycki MB, Barbi G, von Ameln S, Högel J, Degoricija M, Fertig R, Burkhalter MD, Hofmann K, Thiele H, Altmüller J, Nürnberg G, Nürnberg P, Bahlo M, Martin GM, Aalfs CM, Oshima J, Terzic J, Amor DJ, Dikic I, Ramadan K, Kubisch C. Lessel D, et al. Nat Genet. 2014 Nov;46(11):1239-44. doi: 10.1038/ng.3103. Epub 2014 Sep 28. Nat Genet. 2014. PMID: 25261934 Free PMC article.

References

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