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. 2015 Apr;35(4):325-30.
doi: 10.1002/pd.4525. Epub 2015 Feb 16.

Prenatal detection of congenital heart disease in a low risk population undergoing first and second trimester screening

Ditte E S Jørgensen  1 , Niels Vejlstrup, Connie Jørgensen, Lisa Leth Maroun, Jesper Steensberg, Anette Hessellund, Finn Stener Jørgensen, Torben Larsen, Anne-Cathrine Shalmi, Lillian Skibsted, Helle Zingenberg, Charlotte Ekelund, Ann Tabor
Affiliations

Prenatal detection of congenital heart disease in a low risk population undergoing first and second trimester screening

Ditte E S Jørgensen et al. Prenat Diagn. 2015 Apr.

Abstract

Objectives: The prenatal detection rate of congenital heart disease (CHD) is low compared with other fetal malformations. Our aim was to evaluate the prenatal detection of CHD in Eastern Denmark.

Methods: Fetuses and infants diagnosed with CHD in the period 01.01.2008-31.12.2010 were assessed regarding prenatal detection rate and accuracy, as well as correlation with nuchal translucency (NT) thickness.

Results: Out of 86 121 infants, 831 were born with CHD (0.96%). The prenatal detection rate of 'all CHD' was 21.3%, of 'Major CHD' 47.4%. Full agreement between prenatal and postnatal/autopsy findings was found in 96% of prenatally detected diagnoses. An NT thickness >95(th) percentile was found in 15.0% fetuses with 'Major CHD'. Of 'Major CHDs' detected prenatally, 77% were picked up at the time of the malformation scan at weeks 18-21.

Conclusions: Nearly half of 'Major CHDs' were detected prenatally. The prenatal cardiac diagnoses showed a high degree of accuracy. Increased NT thickness as a screening tool for CHD performed moderately but is an important high risk group for specialist examination. A minority of the prenatally detected CHDs was identified because of extra scans performed in high risk pregnancies. © 2014 John Wiley & Sons, Ltd.

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