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Randomized Controlled Trial
. 2014 Sep;14(3):502-9.
doi: 10.4314/ahs.v14i3.2.

Dextrose boluses versus burette dextrose infusions in prevention of hypoglycemia among preterms admitted at Mulago Hospital: an open label randomized clinical trial

E Kutamba  1 , S Lubega  2 , J Mugalu  2 , J Ouma  3 , E Mupere  1
Affiliations
Randomized Controlled Trial

Dextrose boluses versus burette dextrose infusions in prevention of hypoglycemia among preterms admitted at Mulago Hospital: an open label randomized clinical trial

E Kutamba et al. Afr Health Sci. 2014 Sep.

Abstract

Background: Hypoglycemia is a major cause of morbidity and mortality among preterm infants and its management remains a challenge in resource limited settings. Use of dextrose infusion by the recommended infusion pumps is not feasible in our environment due to their high costs and yet the current use of mini dextrose boluses with syringes as adapted at Mulago national referral and tertiary teaching hospital has unknown efficacy in prevention of hypoglycemia.

Objective: We determined the efficacy of dextrose infusions by burettes versus two hourly dextrose boluses in prevention of hypoglycemia among preterms admitted in the first 72 hours at Special Care Unit, Mulago Hospital.

Methods: One hundred and forty preterms aged 0 to 24 hours of life were randomized to receive 10% IV dextrose either as mini boluses or by infusion using burettes in an open label clinical trial. Blood glucose was measured at 0, two hourly for next 6 hours, 6 hourly for next 12 hours and thereafter 12 hourly until end of 72 hours following admission. Primary end point was incidence of hypoglycemia (random blood sugar (RBS) < 2.6 mmol/l) which was expressed as relative risk (RR). Efficacy of the dextrose infusion was computed using 1-RR.

Results: From February 2012 to April 2012, 68 preterms in the bolus arm and 72 in the infusion arm were studied. Hypoglycemia was detected in 34% (48/140). The incidence of hypoglycemia in the bolus arm was 59% (40/68) compared to 11% (8/72) in the infusion arm (RR; 0.19, 95% CI; 0.09-0.37). Efficacy (1-RR) of infusion by burettes versus boluses in prevention of hypoglycemia among preterms was 0.81 (95% CI; 0.63-0.90).

Conclusion: Continuous 10% dextrose infusion by burettes reduced the incidence of hypoglycemia by 81% in the first 72 hours of admission compared to two hourly 10% mini dextrose boluses among preterms admitted at Special Care Unit, Mulago Hospital. (ClinicalTrials.gov Identifier: NCT01688674).

Keywords: Dextrose boluses; burette infusions; hypoglycemia.

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Figures

Figure 2
Figure 2
Time to development of hypoglycemia among preterms receiving 10% dextrose by either two hourly boluses or continuous infusion by burettes
Figure 1
Figure 1
Trial profile
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References

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    1. McGowan JE. Neonatal Hypoglycemia. Pediatrics. 1999;20(6)
    1. Ministry of Health (MOH), author Situation analysis of Newborn health in Uganda; Current status and opportunities to improve care and survival. 2008
    1. World Health Organization (WHO), author Neonatal hypoglycemia. 1997
    1. Special Care Unit, author. Fluid requirements and management in neonates. 2011

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