Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 Jan;63(1):441-4.
doi: 10.1128/JVI.63.1.441-444.1989.

Internal binding of eucaryotic ribosomes on poliovirus RNA: translation in HeLa cell extracts

J Pelletier  1 , N Sonenberg
Affiliations

Internal binding of eucaryotic ribosomes on poliovirus RNA: translation in HeLa cell extracts

J Pelletier et al. J Virol. 1989 Jan.

Abstract

Translation initiation on poliovirus mRNA in poliovirus-infected cells has been shown to occur by internal binding of ribosomes to the 5' noncoding region (J. Pelletier and N. Sonenberg, Nature [London] 334:320-325, 1988). Here we show that internal ribosome binding can occur in HeLa cell extracts in vitro. Internal binding to the 5' noncoding region of poliovirus mRNA in a bicistronic context was independent of the upstream open reading frame and did not require poliovirus proteins.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1982 Jun;79(11):3447-51 - PubMed
    1. J Biol Chem. 1982 Dec 25;257(24):14806-10 - PubMed
    1. Microbiol Rev. 1983 Mar;47(1):1-45 - PubMed
    1. J Virol. 1985 Jun;54(3):720-5 - PubMed
    1. J Virol. 1987 Apr;61(4):986-91 - PubMed

Publication types

Associated data

LinkOut - more resources