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. 1989 Jan;91(1):1-5.
doi: 10.1093/ajcp/91.1.1.

A survey of Epstein-Barr virus DNA in lymphoid tissue. Frequent detection in Hodgkin's disease

S P Staal  1 , R Ambinder, W E Beschorner, G S Hayward, R Mann
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A survey of Epstein-Barr virus DNA in lymphoid tissue. Frequent detection in Hodgkin's disease

S P Staal et al. Am J Clin Pathol. 1989 Jan.

Abstract

A total of 151 unselected malignant and nonmalignant lymphoid tissue samples were surveyed by Southern blotting for the presence of Epstein-Barr virus (EBV) DNA. Eight of 28 Hodgkin's disease (HD) samples (29%) had detectable EBV DNA. Both nodular sclerosis and mixed cellularity histologic results were positive. The tumor type with the next highest frequency, 8%, was diffuse large cell lymphoma. The presence of EBV DNA in some HD biopsies suggests that EBV may be a factor in the pathogenesis of this disease. Alternatively, its presence may be secondary to the immune deficiency characteristic of HD. The clonal B-lymphocyte expansions reported in some cases of HD may result from EBV infection.

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Comment in

  • EBV-DNA in lymphoid tissue.
    Chappuis BB, Müller-Hermelink HK. Chappuis BB, et al. Am J Clin Pathol. 1989 Aug;92(2):255-6. doi: 10.1093/ajcp/92.2.255. Am J Clin Pathol. 1989. PMID: 2547311 No abstract available.

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