Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014;92(6):381-7.
doi: 10.1159/000366066. Epub 2014 Oct 29.

Subthalamic nucleus high-frequency stimulation for advanced Parkinson's disease: motor and neuropsychological outcome after 10 years

Marcus L F Janssen  1 , Annelien A Duits, Ali H Turaihi, Linda Ackermans, Albert F G Leentjens, Albert F G Leentjes, Vivianne van Kranen-Mastenbroek, Mayke Oosterloo, Veerle Visser-Vandewalle, Yasin Temel
Affiliations

Subthalamic nucleus high-frequency stimulation for advanced Parkinson's disease: motor and neuropsychological outcome after 10 years

Marcus L F Janssen et al. Stereotact Funct Neurosurg. 2014.

Erratum in

  • Stereotact Funct Neurosurg. 2014;92(6):387. Tourai, Ali M [corrected to Turaihi, Ali H]
  • Erratum.
    [No authors listed] [No authors listed] Stereotact Funct Neurosurg. 2015;93(1):66A. doi: 10.1159/000373914. Epub 2015 Feb 17. Stereotact Funct Neurosurg. 2015. PMID: 25733104 No abstract available.

Abstract

Background: Since the introduction of subthalamic nucleus deep brain stimulation (STN DBS), many clinical studies have shown that this therapy is safe and effective in the short and medium term. Only little is known about long-term results.

Objectives: To provide an analysis of motor and cognitive outcome 10 years after STN DBS.

Methods: In this observational cohort study, we report on the motor and cognitive outcome in a cohort of 26 Parkinson's disease patients who were prospectively followed up for 10 years after STN DBS surgery.

Results: In the early post-operative phase, improvement in the Unified Parkinson's Disease Rating Scale (UPDRS) III (10.6, p < 0.01) and IV (2.5, p < 0.01) was seen as well as a 32% reduction in levodopa equivalent dose (p < 0.01). After 5 years, a worsening of the motor performance was observed. The worsening of motor performance was mainly due to a deterioration in bradykinesia (12.4 ± 4.6, p < 0.05) and axial symptoms (6.9 ± 2.8, p < 0.01). Memory function seemed to improve in the short term, but there was a significant decline between 1 and 5 years after surgery (p < 0.01). Mood remained relatively stable during follow-up, and one third of the patients showed impulsive behaviour after surgery.

Conclusions: The motor performance of patients showed deterioration over time, due to an increase in bradykinesia and axial symptoms.

PubMed Disclaimer

Publication types