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. 2014 Oct;51(10):801-3.
doi: 10.1007/s13312-014-0505-x.

Genetic factors associated with slow progression of HIV among perinatally-infected Indian children

Riya Pal Chaudhuri  1 , Ujjwal Neogi, Shwetha D Rao, Anita Shet
Affiliations

Genetic factors associated with slow progression of HIV among perinatally-infected Indian children

Riya Pal Chaudhuri et al. Indian Pediatr. 2014 Oct.

Abstract

Objective: To study the association between common AIDS restriction genes and slow disease progression among perinatally-infected children in India.

Methods: ART-naïve children were identified and selected host factors including CCR5-∆32, SDF1-3'A, CCR5-59029G, HLA-B*27, B*57 were studied using allele-specific PCR-RFLP and SSPGo HLA typing kits.

Results: Among 165 children, 10 (6%) long-term non-progressors and 8 (5%) slow progressors were identified. For comparison, 12 children with normal progression of HIV were included. The frequencies of CCR5-∆32 deletion, SDF1-3'A and CCR5-59029G did not differ significantly. HLA-B*27 and B*57 were observed only in long-term non-progressors or slow progressors, who also harbored either SDF1-3'A and/or CCR5-59029G.

Conclusions: There is an association between host genetic factors and slow disease progression in this population.

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Conflict of interest statement

Competing interests: None stated.

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