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Review
. 2014 Nov;29(6):456-69.
doi: 10.1152/physiol.00015.2014.

The sarcoplasmic reticulum and the evolution of the vertebrate heart

Holly A Shiels  1 , Gina L J Galli  2
Affiliations
Free article
Review

The sarcoplasmic reticulum and the evolution of the vertebrate heart

Holly A Shiels et al. Physiology (Bethesda). 2014 Nov.
Free article

Abstract

The sarcoplasmic reticulum (SR) is crucial for contraction and relaxation of the mammalian cardiomyocyte, but its role in other vertebrate classes is equivocal. Recent evidence suggests differences in SR function across species may have an underlying structural basis. Here, we discuss how SR recruitment relates to the structural organization of the cardiomyocyte to provide new insight into the evolution of cardiac design and function in vertebrates.

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