doi: 10.1016/0891-5849(89)90161-5.
Hyperoxia during reperfusion is a factor in reperfusion injury
Affiliations
- PMID: 2536344
- DOI: 10.1016/0891-5849(89)90161-5
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Hyperoxia during reperfusion is a factor in reperfusion injury
Free Radic Biol Med.
1989.
Abstract
Imposition of ischemia should result in accumulation of lactic acid with an attendant drop in pH. Subsequent reperfusion would result in hyperoxia, in the affected tissue, due to the Bohr Effect. O2- should therefore be produced in greater than normal amounts, due to this transient hyperoxia, and may contribute to reperfusion injury. Tissue acidification, during extreme exercise or in diabetes mellitus, may similarly lead to hyperoxia and to tissue damage by O2-.
Comment in
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Hypothesis that the acidification of a tissue which takes place during ischemia can lead to tissue hyperoxia during reperfusion due to the Bohr effect.Free Radic Biol Med. 1990;8(5):487-9. doi: 10.1016/0891-5849(90)90061-m. Free Radic Biol Med. 1990. PMID: 2253898 No abstract available.
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Hyperoxia during reperfusion is a factor in reperfusion injury.Free Radic Biol Med. 1990;8(3):269. doi: 10.1016/0891-5849(90)90073-r. Free Radic Biol Med. 1990. PMID: 2341057 No abstract available.