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. 2014 Dec;41(6):518-20.
doi: 10.1111/iji.12157. Epub 2014 Nov 3.

Polymorphism in IFI16 affects CD4(+) T-cell counts in HIV-1 infection

T Booiman  1 , N A Kootstra
Affiliations

Polymorphism in IFI16 affects CD4(+) T-cell counts in HIV-1 infection

T Booiman et al. Int J Immunogenet. 2014 Dec.

Abstract

Interferon-γ-inducible protein 16 (IFI16) plays a pivotal role in the death of bystander CD4(+) T-cells. Here, we demonstrate that SNP rs1417806 in IFI16 is associated with CD4(+) T-cell counts at set point and HIV-1 disease progression, indicating that IFI16 affects HIV-1 pathogenesis especially during the early phase of infection.

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