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. 2015 Jan;24(1):67-9.
doi: 10.1111/exd.12583. Epub 2014 Dec 8.

Dermal dendritic cells, but not Langerhans cells, are critical in murine single epicutaneous sensitization

Chih-Hung Lee  1 , Jau-Shiuh Chen, Hsien-Ching Chiu, Chien-Hui Hong, Ching-Yi Liu, Yng-Cun Ta, Bjőrn E Clausen, Ji-Chen Ho, Li-Fang Wang
Affiliations

Dermal dendritic cells, but not Langerhans cells, are critical in murine single epicutaneous sensitization

Chih-Hung Lee et al. Exp Dermatol. 2015 Jan.

Abstract

A murine repeated protein-patch model has been established to study epicutaneous sensitization in atopic dermatitis. This model has shown a predominant Th2 and a weak Th1 response in both BALB/c and C57BL/6 mice. However, Th responses induced in the repeated model are not consistent with the generally accepted theory that BALB/c and C57BL/6 mice are Th2 and Th1 prone and are representatives of human atopy and non-atopy, respectively. In this study, a single protein-patch model was established, which showed in addition to the Th2 response, a remarkable Th1 response in C57BL/6 mice, but not in BALB/c mice. Moreover, using muLangerin-DTR mice, we demonstrated that dermal dendritic cells, but not Langerhans cells, are critical in single epicutaneous sensitization in both strains of mice.

Keywords: Th1/Th2; dendritic cell subset; epicutaneous sensitization.

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