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. 2014 Oct 29;1(4):e39.
doi: 10.1212/NXI.0000000000000039. eCollection 2014 Dec.

Autoimmune encephalitis with GABAB antibodies, thymoma, and GABAB receptor thymic expression

Harry Alexopoulos  1 , Ioannis E Dagklis  1 , Sofia Akrivou  1 , Sevasti Bostantjopoulou  1 , Marinos C Dalakas  1
Affiliations

Autoimmune encephalitis with GABAB antibodies, thymoma, and GABAB receptor thymic expression

Harry Alexopoulos et al. Neurol Neuroimmunol Neuroinflamm. .
No abstract available

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Figures

Figure 1
Figure 1. GABAB expression in the thymus
(A–C) Staining of thymus tissue with anti-cytokeratin (A) and anti-GABAB antibody (B, C double immunofluorescence). Cytokeratin-positive epithelial cells express GABAB receptor (arrows). In addition, GABAB is expressed in other cell types of the thymus, most likely T cells (arrowheads). (D–F) Staining of thymus tissue with anti-cytokeratin (D) and patient sera (E, F double immunofluorescence). Patient antibodies clearly co-localize with cytokeratin-positive epithelial cells. The pattern of staining and co-localization in these areas is identical to panels A, B, and C. Due to antibody combination and tissue availability restrictions, we were unable to triple stain for cytokeratin-GABAB-serum. From our results it can be safely inferred that the GABAB serum autoantibodies bind GABAB that is expressed in thymic epithelial cells. GABAB = γ-aminobutyric acid receptor B.
See this image and copyright information in PMC

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