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. 2015 Feb 15;60(4):608-10.
doi: 10.1093/cid/ciu865. Epub 2014 Nov 2.

Low relapse rate leads to high concordance of sustained virologic response (SVR) at 12 weeks with SVR at 24 weeks after treatment with ABT-450/ritonavir, ombitasvir, and dasabuvir plus ribavirin in subjects with chronic hepatitis C virus genotype 1 infection in the AVIATOR study

Fred Poordad  1 , Kosh Agarwal  2 , Ziad Younes  3 , Daniel Cohen  4 , Wangang Xie  4 , Thomas Podsadecki  4
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Low relapse rate leads to high concordance of sustained virologic response (SVR) at 12 weeks with SVR at 24 weeks after treatment with ABT-450/ritonavir, ombitasvir, and dasabuvir plus ribavirin in subjects with chronic hepatitis C virus genotype 1 infection in the AVIATOR study

Fred Poordad et al. Clin Infect Dis. .

Abstract

In 247 subjects with hepatitis C virus genotype 1 infection treated with the interferon-free regimen of ABT-450/ritonavir, ombitasvir, and dasabuvir plus ribavirin, concordance of a sustained virologic response at 12 and 24 weeks supports the use of the earlier time point as a primary efficacy endpoint for trials of this interferon-free regimen.

Keywords: concordance; direct-acting antivirals; hepatitis C; sustained virologic response.

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