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Comment
. 2014 Nov;22(11):1886-8.
doi: 10.1038/mt.2014.190.

A theranostic "SMART" aptamer for targeted therapy of prostate cancer

Vittorio de Franciscis  1
Affiliations
Comment

A theranostic "SMART" aptamer for targeted therapy of prostate cancer

Vittorio de Franciscis. Mol Ther. 2014 Nov.
No abstract available

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Figures

Figure 1
Figure 1
In vivo therapeutic efficacy of the A9g PSMA aptamer. By binding prostate-specific membrane antigen (PSMA), the A9g aptamer blocks NAALADase/glutamate carboxypeptidase II activity and inhibits PSMA-dependent cell migration and invasion in cancer cells in a mouse model of metastatic prostate cancer. Severe combined immunodeficiency mice were treated with the indicated aptamers and analyzed following injection of luciferase-expressing PSMA-positive prostate cancer cells. Modified from ref. .
See this image and copyright information in PMC

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