Short and long sleep durations are both associated with increased risk of stroke: a meta-analysis of observational studies

Abstract

Background: There is uncertainty about the relationship between sleep duration and stroke risk.

Aim: We aimed to clarify the relationship between sleep duration and risk of stroke by using epidemiological evidence.

Methods: We searched MEDLINE and EMBASE to identify all studies that might be looking at the association between sleep duration and stroke, including both cohort and cross-sectional studies. Pooled hazard ratios (HRs) and odds ratios (ORs) were calculated through a random-effects model.

Results: Our study included a total of 12 cohort studies and 6 cross-sectional studies. Pooled results from the cohort studies showed that short sleep duration was associated with a higher risk for stroke [HR, 1.13; 95% confidence interval (CI) 1.02-1.25], and that long sleep duration also increases the risk of having a stroke (HR, 1.40; 95% CI, 1.16-1.64). Results from cross-sectional studies confirmed the relationship between stroke and inappropriate sleep duration, either too little sleep or too much. For short sleep duration, the OR was 1.71 (1.39-2.02); for long sleep duration, the OR was 2.12 (1.51-2.73).

Conclusion: Both short and long sleep durations have a significant association with higher risk of stroke.

Keywords: long sleep duration; meta-analysis; observational studies; short sleep duration; stroke.